Muzvisikwa, mannose iripo mune yakasununguka mamiriro mune mimwe michero, yakadai secranberries, maapuro, maranjisi, etc. Mumuviri wemunhu, mannose inoparadzirwa mumatumbu ose neropa, kusanganisira ganda, nhengo uye nerve. Mune aya matishu, mannose inobatanidzwa mukuumbwa kweglycoprotein inogadzirisa basa re autoimmune system. Ongororo dzekiriniki dzakapfuura dzakaratidza kuti mannose inogona kurapa uye kudzivirira weti turakiti hutachiona, saka zvimwe zvekunze zvigadzirwa zvehutano zvine mannose sechinhu chikuru chinoshandiswa kuchengetedza weti system hutano.

Zvagara zvichizivikanwa kuti mabundu ane kudiwa kwakanyanya kweglucose pane akajairwa tishu. Masero ebundu anogona kutora kusvika kagumi glucose yakawanda semasero akajairwa uye anovimba zvakanyanya neglycolysis yesimba kuti arambe achikura nekukurumidza. Zvisinei, "shuga sehupenyu" bundu, pamberi pemannose, asi mamiriro akasiyana akaitika. Muna 2018, bhuku rinonzi Nature rakaburitsa blockbuster ongororo kubva kuCancer Research UK kuti mannose inogona kumisa mapundu. Vatsvakurudzi vakawana kuti mushure mokunge mannose yapinda mumaseru ebundu, inoungana mukati memasero muchimiro chemannose 6-phosphate, ichivharira simba rebundu nekukanganisa metabolism yeglucose, nokudaro ichidzivisa kukura kwemasero emarara. Kuti vasimbise mhedziso iyi, vaongorori vakaita kumwe kuongorora mune yembeva tumor modhi, vakawedzera mannose kumvura yekunwa yeaya "kenza" mbeva, uye vakaongorora mhedzisiro yemuromo mannose pakurapa kwemhando dzakasiyana dzegomarara senge pancreatic cancer uye kenza yemapapu mumakonzo. Mhedzisiro yacho yakaratidza kuti kutonga nemuromo kwemannose nekunwa mvura kunonoka kunonoka bundu kukura mumakonzo. Mushure mekusimbisa kurapa kwemannose mune yembeva tumor modhi, vaongorori vakafunga kupa mannose kune mbeva kuwedzera kune chemotherapy yekurapwa adjuvant, uye vakashamisika kuona kuti mannose inosimudzira kurapa kwechemotherapy, kwete kungowedzera kudzikisa bundu vhoriyamu mumakonzo, asi zvakare nekuwedzera hupenyu hwe "cancerous" mice. Gore rino, timu yeFudan University yekutsvagisa yakawana nzira nyowani yemannose anti-cancer - inodzora immune checkpoint molecule PD-L1. Chii chinonzi tumor immune checkpoint? Isu tinoziva kuti kana miviri yekunze senge mabhakitiriya ekunze uye mavhairasi apinda kana maseru emuviri akafa kana kuita gomarara, immune system yemuviri wemunhu inozoitwa, uye immune system ichaita basa mushure mekushandiswa kubvisa aya "mamorekuru ekunze". Panguva imwecheteyo, kuitira kuti udzivise kuwedzera-activation ye immune system uye "kuuraya zvisina tsarukano" kweakajairika matishu maseru mumuviri, pane seti ye "immune checkpoint molecules" mumuviri wedu. PD-L1 yakakosha immune yekutarisa mamorekuru mumuviri wedu, iyo inogona kusunga kune iyo PD-1 molecule iri pamusoro pemasero edziviriro uye kutumira chiratidzo che "brake" kumaseru ekudzivirira kudzivirira kuurayiwa kwemaseru akajairwa nemasero ekudzivirira (Mufananidzo 2). Nekudaro, iyi brake system mumuviri wedu inoshandisirwa nemanomano bundu maseru, uye T maseru ari mubundu microenvironment ane basa rekuuraya mabundu, uye masero ebundu anoburitsa ma "brake" masaini kumasero eT kuburikidza nekutaura kwakanyanya kwePD-L1 mamorekuru, kuvharira kuita kweT masero, kuitira kudzivirira kuurayiwa kwe immune system.

PD-L1 molecule ipuroteni yakapfuma mukugadzirisa glycosylation. Chikwata chekutsvagisa cheFudan University chakawana kuti mannose inogona kuparadza kugadzikana kwePD-L1 protein nekugadzirisa glycosylation yePD-L1 mamorekuru, nekudaro ichikurudzira kuparara kwePD-L1 mamorekuru. Saka, kana iyo yakanyanya kuratidzwa PD-L1 morekuru mumaseru bundu yakaderedzwa nemannose, maseru ebundu haamanikidzire T masero "kubhureka"? Vatsvakurudzi vakasimbisa fungidziro: masero emamota akabatwa nemannose ainyanya kuurayiwa neT masero; Mumuenzaniso wemouse tumorum, oral mannose inogona kukurudzira kupinda uye kuuraya kweT masero kune bundu uye kutadzisa kukura kwebundu, uye kusanganiswa kwemannose uye immune checkpoint antibody zvinodhaka zvinowedzera kukurudzira kupinda nekuuraya kweT masero kune bundu, uye inowedzera zvakanyanya hupenyu hwe "gomarara" mbeva.

Sezvatakambotaura, mannose inowanikwa zvakasikwa mune mamwe michero, kunyanya cranberries ine yepamusoro mannose content (Mufananidzo 3). Vanhu vazhinji vangave vachishamisika, kudya cranberries kunogona kudzivirira kana kurapa cancer? Muchokwadi, kuwanda kwemannose yakapihwa "cancer" mbeva muzvidzidzo zviviri zviri pamusoro apa kwakakwira kusvika 20%, zvinoreva kuti 100ml yega yega yemvura yekunwa ine 20g yemannose, inova yakanyanya kukwirisa uye dose. Nokudaro, tinodya cranberries nemimwe michero kuti tiwedzere kudya kwemannose, kune imwe nzvimbo, inogona kukurudzira kudzivirirwa, kunobatsira kune hutano, asi kuda kuwana mhedzisiro ye-anti-cancer cranberries chete iri kure zvakakwana.